The work of the Kizhakkedathu lab has been featured in numerous high-impact journals such as Nature Materials, Nature Biomedical Engineering, Nature Microbiology, ACS Nano, Advanced Functional Materials, etc. Continue below to explore major research themes in our laboratory through selected publications.
Click the images below to jump to publications by research area. For additional publications, see Jay’s Google Scholar page.
Antithrombotic Molecules, Surfaces, and Inhibitors
- Herrmann, A. et al. An Ultrahydrating Polymer that Protects Protein Therapeutics and RNA-Lipid Nanoparticles Against Freezing, Heat and Lyophilization Stress. Advanced Functional Materials 34, 2406878 (2024). Read in Advanced Functional Materials
- La, C. C. et al. External Trigger Free Charge Switchable Cationic Ligands in the Design of Safe and Effective Universal Heparin Antidote. Advanced Healthcare Materials 13, 2400108 (2024). Read in Advanced Healthcare Materials
- La, C. C. et al. Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design. Nat Commun 14, 2177 (2023). Read in Nature Communications
- Abbina, S., Abbasi, U., Gill, A., Leitch, H. & Kizhakkedathu, J. N. Active transport nanochelators for the reduction of liver iron burden in iron overload. Journal of Controlled Release 350, 857–869 (2022). Read in Journal of Controlled Release
- Abbina, S. et al. Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface. Nat Commun 11, 3048 (2020). Read in Nature Communications
- Kalathottukaren, M. T. et al. Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA. Blood 129, 1368–1379 (2017). Read in Blood
- Shenoi, R. A. et al. Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants. Science Translational Medicine 6, 260ra150-260ra150 (2014). Read in Science Translational Medicine
Glycocalyx Engineering
- Luo, H. D. et al. Investigation on Adaptability and Applicability of Polymer-Mediated Cell Surface Engineering by Ligation with Transglutaminase. ACS Appl. Mater. Interfaces 16, 15893–15906 (2024). Read in ACS Applied Materials & Interfaces
- Siren, E. M. J. et al. Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers. Nat Biomed Eng 5, 1202–1216 (2021). Read in Nature Biomedical Engineering
- Rahfeld, P. et al. An enzymatic pathway in the human gut microbiome that converts A to universal O type blood. Nat Microbiol 4, 1475–1485 (2019). Read in Nature Microbiology
- Chapanian, R. et al. Enhancement of biological reactions on cell surfaces via macromolecular crowding. Nat Commun 5, 4683 (2014). Read in Nature Communications
- Yu, X. et al. Polyvalent choline phosphate as a universal biomembrane adhesive. Nature Mater 11, 468–476 (2012). Read in Nature Materials
Tissue + Organ ImmunoEngineering
- Ji, H. et al. Antithrombotic coating with sheltered positive charges prevents contact activation by controlling factor XII–biointerface binding. Nat. Mater. 1–11 (2024) doi:10.1038/s41563-024-02046-0. Read in Nature Materials
- Xu, T. et al. Self-anticoagulant sponge for whole blood auto-transfusion and its mechanism of coagulation factor inactivation. Nat Commun 14, 4875 (2023). Read in Nature Communications
- Yu, K., Andruschak, P., Yeh, H. H., Grecov, D. & Kizhakkedathu, J. N. Influence of dynamic flow conditions on adsorbed plasma protein corona and surface-induced thrombus generation on antifouling brushes. Biomaterials 166, 79–95 (2018). Read in Biomaterials
Antimicrobial Surfaces
- Yazdani-Ahmadabadi, H. et al. Long-Term Prevention of Biofilm Formation by Polycatechol-Based Supramolecular Assemblies with Low Molecular Weight Polymers on Surfaces. ACS Appl. Mater. Interfaces 16, 38631–38644 (2024). Read in ACS Applied Materials & Interfaces
- Yazdani-Ahmadabadi, H. et al. Durable Surfaces from Film-Forming Silver Assemblies for Long-Term Zero Bacterial Adhesion without Toxicity. ACS Cent. Sci. 8, 546–561 (2022). Read in ACS Central Science
- Mei, Y. et al. Polymer–Nanoparticle Interaction as a Design Principle in the Development of a Durable Ultrathin Universal Binary Antibiofilm Coating with Long-Term Activity. ACS Nano 12, 11881–11891 (2018). Read in ACS Nano
- Yu, K. et al. Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model. Biomaterials 116, 69–81 (2017). Read in Biomaterials